In vitro eye embryogenesis from induced pluripotent stem cells for ocular surface disease treatment
In their letter to Nature, Hayashi et al. describe a new method for the generation of ocular surface epitheliumlike cells by incubating human induced pluripotent stem cells (iPS) into four defined concentric zones mimicking the developing eye, which the authors named as self-formed ectodermal autonomous multi-zone (SEAM) (1). Different SEAM zones contained cells with characteristics of the ocular surface ectoderm, the lens, the neural retina and the retinal pigment epithelium. Isolated corneal surface-like cells successfully reinstated a corneal epithelium in a rabbit limbal stem cell deficiency (LSCD) model. The paper offers a new option for patients with LSCD.