Article Abstract

Correlation of polymorphism of MMP-3 gene with the risk of type 2 diabetic retinopathy

Authors: Jie Yang, Tiemin Zhang, Xiucheng Cui, Yinghui Ma, Hongmei Wang

Abstract

Objective: To determine the correlation between polymorphism at MMP-3 gene and risk of type 2 diabetic retinopathy (DR).
Methods: In a hospital-based case-control study, MMP-3 SNP was genotyped by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis in 195 diabetic retinopathy patients, 205 diabetes mellitus patients and 261 healthy persons as control.
Results: There is no significant difference between the Control groups, DM group and DR group in allele or genotype distributions of MMP-3-1171 5A/6A (P=0.474 and P=0.407). There is no significant difference between the NPDR and PDR group in allele or genotype distributions of MMP-3-1171 5A/6A (P=0.724 and P=0.820).
Conclusion: There is no significant difference between the Control groups, DM group and DRgroup in allele or genotype distributions of MMP-3 -1171 5A/6A.

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